By Sara Amundson and Kitty Block

For the 190 million animals used in testing and research each year around the world, the shift to non-animal methods cannot come soon enough.

We have always been determined to see a day when elected officials, heads of major government agencies, and the leaders of scientific institutions and corporations came around to the position we have held for a long time:

That we need not rely on animals to gauge the safety of chemical and pesticide products.

Update June 4, 2026: The U.S. House of Representatives passed its FY 2027 federal funding bill for the USDA and the FDA with a vote of 213 - 210. The Senate Appropriations Committee has not yet released its version of this bill. One positive note from today’s floor debate: the House approved two amendments led by Rep. Nicole Malliotakis (R-N.Y.)—to prevent FDA from issuing guidelines calling for dog testing and to prevent USDA from conducting or funding painful research on dogs or cats.  

By Sara Amundson and Kitty Block

Over 90% of drugs that appear successful in animal tests go on to fail in human clinical trials. This is a staggering statistic underscoring that animals are biologically different from humans, and so animal-based research can be deeply unreliable, which, in turn, hinders medical progress and slows down the advancement of our scientific knowledge. Even more closely related species like mice and rats can react very differently when exposed to the same substances.

Across the world, an estimated 190 million animals are used for testing and research every year. Many of these animals, including mice, rats, rabbits, monkeys, dogs and fish, are used to explore how human bodies may respond to chemicals. But there are major differences between animals and humans, and immense advancements in technology that hold promise for replacing the use of animals in these tests.

By Sara Amundson and Kitty Block

Making this world better and brighter for animals involves vital collaboration with people in the halls of power making legislation and shaping policy. In the U.S., we work on bringing people together—regardless of party affiliation—to advance compassionate legislation that makes a real difference for animals.